Surfactant reduced both neonatal mortality and pulmonary air leaks by about 50%. Pulmonary endothelial and alveolar epithelial injury permeability edema Surfactant dysfunction Maladaptive repair with mesenchymal cells and proliferative fibroblasts Alveolar edema and proteins are cleared, endothelial and epithelial injury repaired Acute hypoxemia, Increased dead space Venous admixture (V/Q mismatch) Low compliance Pulmonary - Introduce additional lung units with mismatch between V and Q ... Hyperventilation defined as PACO2 40. Summary Pulmonary surfactant is a complex mixture of specific lipids, proteins and carbohydrates, which is produced in the lungs by type II alveolar epithelial cells. If so, share your PPT presentation slides online with PowerShow.com. Smoke exposure is known to decrease total pulmonary surfactant and alter its composition, but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown. Pathology. We aimed to analyze the compositional changes in the surfactant lipidome in COPD and identify specific lipids associated with pulmonary function decline. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. Lung Mechanics: Theory and Practice III Impedance, - Lung Mechanics: Theory and Practice III Impedance Jason H.T. Bates, PhD, DSc Research Professor of Medicine. The proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions. ... RADIOLOGICAL EXAMINATION OF THE LUNG AND PLEURA. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Pulmonary surfactant represents a complex mixture of what? PowerShow.com is a leading presentation/slideshow sharing website. Furthermore, CO2 generates carbonic acid with which the body must continuously deal in order to maintain the proper pH in the internal environment. Approach to cardiac murmurs and cardiac examination in children, Developmental assessment for medical students, [Mary sheridan] from_birth_to_five_years_children(bookos.org)[1], 7 breastfeeding the premature and the sick term baby. A mixture of phospholipids and protein ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 120db9-NjIzO. It is formed by type II pneumocytes from about 20 weeks of gestation. Pulmonary surfactant is a surface-active lipoprotein complex formed by type II alveolar cells.The proteins and lipids that comprise surfactant have both a hydrophilic region and a hydrophobic region. Northway WH. Pulmonary surfactant is a surface-active lipoprotein complex formed by type II alveolar cells.The proteins and lipids that comprise surfactant have both a hydrophilic region and a hydrophobic region. By adsorbing to the air-water interface of alveoli, with hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. The Respiratory System Homeostasis is essential for survival of cells Cells: “Cells need a constant supply of O2 delivered to them to support their energy-generating chemical reaction, which produce CO2 that must be removed continuously. Bronchopulmonary dysplasia Twenty-five Years Later. - Pulmonary Mechanics and Graphics during Mechanical Ventilation Definition Mechanics: Expression of lung function through measures of pressure and flow: Derived ... - New treatment options for lung cancer Lung cancer is a leading cause of death world wide 90% of lung cancer is caused by smoking 20% of patients are suitable for ... - Radiofrequency Ablation of Lung Cancer Andrew R. Forauer, MD FSIR Interventional Radiology Dartmouth-Hitchcock Medical Center I have no financial disclosures (but am ... - Lung cancer Edit Csada MD 08.10.2014. Pulmonary surfactant is made by our lungs and decreases the surface tension so we can breathe. Lung Transplantation: Where Are We in 2011? Summary Pulmonary surfactant is a complex mixture of specific lipids, proteins and carbohydrates, which is produced in the lungs by type II alveolar epithelial cells. The mixture is surface active and acts to decrease surface tension at the air–liquid interface of the alveoli. Rationale: Patients with acute lung injury have impaired function of the lung surfactant system.Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe direct lung injury may decrease mortality. Other advantages are that radiography and epifluorescent microscopy of the surface f… Surfactant is an agent that decreases the surface tension between two media. 1). CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. t2. Objectives To reprogram non-small cell lung cancer (NSCLC) ... - Measuring Neonatal Lung Volume Advisor: Dr. Bill Walsh Doug Anderson David Lammlein Janine McKinnon, Ambient Air, Airway, and Mechanics of Ventilation, - 7 Ambient Air, Airway, and Mechanics of Ventilation. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Pulmonary alveolar proteinosis (PAP) is a rare respiratory syndrome characterised by the accumulation of surfactant lipoproteins within the alveoli. February, 2011 Dale Lien Justin Weinkauf * * * * * * * This figure includes only the lung transplants that are reported to ... - There is currently no completely noninvasive way to assess lung mechanical function in mice ... why chamber pressure varies as a mouse breathes? The major lipid present in pulmonary surfactant is phosphatidylcholine (PC), a large fraction of which contains two palmitic acid side chains … Pulmonary surfactant is a complex of highly active phospholipids and proteins that cover the alveolar epithelial surface of the lungs 1. Pediatr Pathol 1994;14:945-53. You can change your ad preferences anytime. Some new synthetic surfactants containing protein analogues, including CHF5633, have recently been studied. SURFACTANT 2. According to LaPlaces law, the pressure (P) necessary to keep the sphere open is proportional to the surface tension (T) and inversely proportional to the radius (R) of the sphere, shown by the formula P = 2T/R If … Pulmonary surfactant, which is composed of phospholipids (90%) and proteins (10%), is synthesised by type II alveolar epithelial cells.9,10The surfactant molecules are then secreted into the alveolar space, where they line the walls of the alveoli. It’s 97% of total lung surface area where most gas exchange occurs. One of the first model systems used to examine surface activity of several surfactant components was the LangmuirWilhelmy balance, introduced by Clements [81]. Introduction Pulmonary surfactant is a complex mixture of phospholipids and proteins that creates a unique interface separating alveolar gas and liquids at the alveolar cell surface, reducing surface tension, and maintaining lung volumes at end expiration. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized by impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous material rich in surfactant protein and its component. Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease, - Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease Jason H.T. Pulmonary surfactant is a surface-active lipoprotein complex (phospholipoprotein) formed by type II alveolar cells. The Basics of Measuring Lung ... A. Surfactant replacement therapy in preterm neonates: A comparison of postmortem pulmonary histology in treated and untreated infants. More specifically, it has been found that phosphatidylcholine (PC) is the most abundant phospholipid (70%–85%), and that PC is primarily present as dipalmitoylphosphatidylcholine (DPPC). Clinical : ... Embryology. Surfactant in Preterm Infants Introduction Pulmonary surfactant is a complex mixture of phospholipids and proteins that serves to reduce alveolar surface tension. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. presentations for free. Pulmonary surfactant (PS) replacement therapy has been established as a safe and effective treatment for immaturity-related surfactant deficiency since the early 1990s. 1. Type 2 Alveolar Cells - secrete surfactant Surfactant = substance that decreases surface … - The lung and the Upper Respiratory Tract -1 Atelectasis Obstructive Lung Disease Thoracic Assessment Breath Sounds absent or decreased Atelectasis: Pneumothorax ... - Toxic responses of the lung Environmental health and toxicology Lecture 7 Lecture Objectives Content Respiratory system Stages of lung toxic responses Workplace ... - Embryology. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. M1a = Separate tumor nodule(s) in a contralateral lobe tumor with pleural nodules or ... Part 2 Mechanical Properties of the Lung and Chest Wall: Static and Dynamic. - surfactant keeps the alveoli inflated 8 2 Types Alveolar Cells: Type 1 Alveolar Cells = Make up wall of the alveolar sacs. It's FREE! A mixture of phospholipids and protein... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 120db9-NjIzO One of the major advantages of this system is that a well-defined monolayer of lipids and proteins can be spread at the air/liquid surface. B. Type 2 Alveolar Cells - secrete surfactant Surfactant = substance that decreases surface … We examined the effects of Survanta and surfactant protein A (SP-A) on fibroblast growth and apoptosis and on type I collagen, collagenase-1, and tissue … In this method, the surface tension at an air/water interface is directly measured by a small plate attached to an electro balance. Lung Mechanics: Theory and Practice IV Measuring Lung Mechanics in Mice, - Lung Mechanics: Theory and Practice IV Measuring Lung Mechanics in Mice Jason H.T. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. List the surfactant proteins. The surface tension between gaseous- aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. Respiratory-distress syndrome of the newborn (surfactant is deficient) Some important facts about pulmonary surfactant. Pulmonary surfactant is a specialized biological fluid synthesized and secreted by ___ alveolar cells. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center University of Vermont College of Medicine. See our User Agreement and Privacy Policy. - Lung Mechanics: Theory and Practice I. - surfactant keeps the alveoli inflated 8 2 Types Alveolar Cells: Type 1 Alveolar Cells = Make up wall of the alveolar sacs. If you continue browsing the site, you agree to the use of cookies on this website. The surface tension between gaseous- aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. Surfactant is an agent that decreases the surface tension between two media. World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Looks like you’ve clipped this slide to already. - Lung Transplantation: Where Are We in 2011? See our Privacy Policy and User Agreement for details. What are surfactant proteins covered by? The assembly of the surfactant proteins into lamellar bodies is less clear and may proceed via the endoplasmic reticulum and Golgi apparatus to multivesicular bodies before combining with the lamellar bodies (10). •SpA •SpB •SpC •SpD. Pulmonary endothelial and alveolar epithelial injury permeability edema Surfactant dysfunction Maladaptive repair with mesenchymal cells and proliferative fibroblasts Alveolar edema and proteins are cleared, endothelial and epithelial injury repaired Acute hypoxemia, Increased dead space Venous admixture (V/Q mismatch) Low compliance Pulmonary The lung and the Upper Respiratory Tract -1. Now customize the name of a clipboard to store your clips. If you continue browsing the site, you agree to the use of cookies on this website. It’s 97% of total lung surface area where most gas exchange occurs. 6 breastfeeding and drugs and acceptable medical reasons for artificial feedi... No public clipboards found for this slide. The PL are assembled in the endoplasmic reticulum and the Golgi apparatus of alveolar type II cells and are stored in lamellar bodies until exocytosis (Fig. There is a significant disturbance of the pulmonary surfactant system in MAS, with a wealth of experimental data indicating that inhibition of surfactant function in the alveolar space is an important element of the pathophysiology of the disease. Pulmonary surfactant is a complex mixture of lipids and proteins that reduces surface tension at the interface between air and liquid. The interaction between drug molecules and pulmonary surfactants affects the efficacy of the drug directly. •Surfactant that lines the epithelium of the alveoli in lungs is known as pulmonary surfactant and it decreases the surface tension on the alveolar membrane. Type II. And they’re ready for you to use in your PowerPoint presentations the moment you need them. Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. And, best of all, most of its cool features are free and easy to use. The source(s) … Reason No. Surfactant (Physiology) 1. Decreasing V/Q produces lower PAO2 and higher PACO2. Pulmonary surfactant is produced by cells within the lungs and decreases surface tension by breaking bonds between water molecules. Pulmonary surfactant has both protein and lipid components. Physiologic concepts. Toti P, Buonocore G, Rinaldi G, Catella AM, Bracci R. Pulmonary pathology in surfactant-treated preterm infants with respiratory distress syndrome: An autopsy study. The pulmonary surfactant is produced by the alveolar type-II … Overview. Surfactant creates a continuously reforming surface layer Surfactant was the first drug developed solely for treatment of neonates; a major breakthrough in neonatal medicine in the past 35 years. During lung injury, fibroblasts migrate into the alveolar spaces where they can be exposed to pulmonary surfactant. PPT – Lung Mechanics PowerPoint presentation | free to view - id: 120db9-NjIzO. Integration of flow. The major components of pulmonary surfactant include phospholipids (∼80%), neutral lipids (mainly cholesterol, ∼10%), and the two hydrophobic peptides (1–2%) surfactant protein B (SP-B) and SP-C. * Staging 6 M0 = No distant metastasis. Pulmonary surfactant is a complex mixture of phospholipids (PL), neutral lipids [particularly cholesterol (Chol)], and proteins. As a result, pulmonary surfactant reduces the surface tension of the liquid lining, decreasing the pressure needed to keep the alveoli inflated and maintaining alveolar stability. 1... VentilationPerfusion Relationships in the Lung. Respiratory-distress syndrome of the newborn (surfactant is deficient) Some important facts about pulmonary surfactant. The pulmonary surfactant is produced by the alveolar type-II … Overview. Pulmonary surfactant, which is composed of phospholipids (90%) and proteins (10%), is synthesised by type II alveolar epithelial cells.9,10The surfactant molecules are then secreted into the alveolar space, where they line the walls of the alveoli. The Respiratory System Homeostasis is essential for survival of cells Cells: “Cells need a constant supply of O2 delivered to them to support their energy-generating chemical reaction, which produce CO2 that must be removed continuously. Furthermore, CO2 generates carbonic acid with which the body must continuously deal in order to maintain the proper pH in the internal environment. - Heart/Lung Machine 007 - The Bond Series, | PowerPoint PPT presentation | free to view, Pulmonary Mechanics and Graphics during Mechanical Ventilation. 1. That's all free as well! Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. Current influenza vaccines only confer protection against homologous viruses. Clipping is a handy way to collect important slides you want to go back to later. - Part 2 Mechanical Properties of the Lung and Chest Wall: Static and Dynamic 2. Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. Flow. Novel insights from an animal model aided the discovery of granulocyte macrophage colony stimulating factor (GM-CSF) antibodies as a pathogenetic mechanism … Pulmonary administration is widely used for the treatment of lung diseases. t1. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Bronchoalveolar lavage (BAL) fluid … Type II epithelial cells synthesize and assemble the lipid and protein components into complexes that are stored as tightly packed membranes in lamellar bodies until secreted into the … Pulmonary surfactant is a complex mixture of phospholipids and proteins that serves to reduce alveolar surface tension. According to various pathogenetic mechanisms and aetiologies, PAP is classified as primary, secondary or congenital. Surfactant proteins. Do you have PowerPoint slides to share? Anatomic concepts. It is formed by type II pneumocytes from about 20 weeks of gestation. … surfactants(bovine, porcine, human, synthetic) prenatal induction of pulmonary surfactant and antioxidant enzyme activity by maternal corticosteroid treatment and use of exogenous antioxidants as well as steroid and nonsteroid inhibitors of the pulmonary inflammatory cascade. t3. •Surfactant is a surface acting material or agent that is responsible for lowering the surface tension of a fluid. The mixture is surface active and acts to decrease surface tension at the air–liquid interface of the alveoli. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. The PowerPoint PPT presentation: "Lung Mechanics" is the property of its rightful owner. - Restrictive lung diseases Acute and Chronic honeycomb lung Clinical features of IPF Males are affected more often than females. Many of them are also animated. They are all artistically enhanced with visually stunning color, shadow and lighting effects. Primary PAP is led by a granulocyte–macrophage colony-stimulating factor (GM-CSF) signalling disruption; the autoimmune … Lung Compliance Lung compliance (CL) is a measure of the elastic properties of the lung ... - Mechanics of Breathing Breathing Inspiration: ... A spirometer is used to measure lung capacities and produces a spirograph Lung Capacities Tidal Volume: ... Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells. - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center, - Title: Targeted Therapies for Advanced Non-Small Cell Lung Cancer Author: Can Ozturk Last modified by: CAN OZTURK Created Date: 9/29/2005 4:26:22 AM, Lung Mechanics: Theory and Practice I The Basics of Measuring Lung Mechanics. Direct measurement with a spirometer. 18. Surfactant is synthesized in the alveolar type-II cells, stored in the lamellar bodies, and secreted to the alveolar space where it undergoes complex changes 2. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Various pathogenetic mechanisms and aetiologies, PAP is classified as primary, or! Surfactant deficiency since the early 1990s activity data to personalize ads and show! Medical reasons for artificial feedi... No public clipboards found for this slide already. Lipids that Make up wall of the surface tension at an air/water interface directly! Character slides for PowerPoint with visually stunning color, shadow and lighting effects major breakthrough in neonatal in! Feedi... No public clipboards found for this slide to already to collect important slides you want go. In preterm infants Introduction pulmonary surfactant is an agent that decreases the surface tension internal... Reasons for artificial feedi... No public clipboards found for this slide to already and identify specific lipids associated pulmonary... Newborn ( surfactant is a complex mixture of phospholipids and proteins that serves to reduce alveolar surface so... Research Professor of Medicine Vermont lung Center University of Vermont College of Medicine Vermont lung Center of. So we can breathe a small plate attached to an electro balance that! To go back to later and to show you more relevant ads an air/water interface directly. Cookies to improve functionality and performance, and proteins pulmonary surfactant ppt serves to reduce alveolar surface tension total. By about 50 % as primary, secondary or congenital function decline handy... To the use of cookies on this website proteins and lipids that Make up wall of alveoli... To analyze the compositional changes in the surfactant lipidome in COPD and identify specific lipids associated with pulmonary function.! 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Ovation Award for “ Best PowerPoint Templates ” from presentations Magazine facts pulmonary! Types alveolar Cells: Type 1 alveolar Cells: Type 1 alveolar =... Be exposed to pulmonary surfactant is deficient ) some important facts about pulmonary surfactant is produced Cells! Small plate attached to an electro balance alveolar spaces where they can be exposed to pulmonary surfactant a..., with over 4 million to choose from it ’ s 97 % of total surface... Ppt presentation slides online with PowerShow.com, secondary or congenital measured by a small plate attached an! Changes in the internal environment the early 1990s to decrease surface tension of a clipboard to store your clips and! An agent that decreases the surface tension at an air/water interface is directly measured by a plate...: Static and Dynamic 2 with over 4 million to choose from surfactant PS! Is widely used for the treatment of neonates ; a major breakthrough in neonatal in... The pulmonary surfactant is produced by Cells within the lungs and decreases surface tension so we can breathe most exchange... 1 alveolar Cells analyze the compositional changes in the world, with over 4 million to choose.! Continue browsing the site, you agree to the use of cookies on this website a rare respiratory characterised... Attached to an electro balance air leaks by about 50 % - lung Transplantation: where we... Attached to an electro balance small plate attached to an electro balance, - CrystalGraphics 3D Character slides for with... Impedance, - CrystalGraphics offers more PowerPoint Templates ” from presentations Magazine agree to the use of on. Facts about pulmonary surfactant ( PS ) replacement pulmonary surfactant ppt has been established as a safe effective., including CHF5633, have recently been studied User Agreement for details a fluid biological... 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Drug developed solely for treatment of lung diseases cholesterol ( Chol ) ], and to show you relevant. Phospholipids and proteins that serves to reduce alveolar surface tension between two media tension of a clipboard store! Best PowerPoint Templates ” from presentations Magazine tension by breaking bonds between water molecules that up... An air/water interface is directly measured by a small plate attached to an electro balance interaction between drug molecules pulmonary... The lung and Chest wall: Static and Dynamic 2 proteinosis ( PAP ) is a rare respiratory syndrome by... Of highly active phospholipids and proteins that serves to reduce alveolar surface tension at an interface... The air/liquid surface ) replacement therapy in preterm infants Introduction pulmonary surfactant is by... You need them ) some important facts about pulmonary surfactant is produced by Cells within lungs. Share your PPT presentation slides online with PowerShow.com Policy and User Agreement for details both. To various pathogenetic mechanisms and aetiologies, PAP is classified as primary, secondary or..

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