Sprague Dawley rat: ( sprāg daw'lē rat ) Common laboratory animal used for experimentation. The SRG rats have a smaller spleen compared to wild-type Sprague Dawley rats and are essentially athymic (Fig 1J–1L), resulting in low viable cell yield from the thymus. Coat Color: White (Albino) Research Applications: General Multipurpose Model; Safety & Efficacy Testing; Aging; Nutrition; Diet-induced Obesity; Oncology; Product Name Surface Marker Analysis Viability; Sprague Dawley Rat Splenocytes: Related … "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. The rats’ obesity was induced by a high-fat (HF) diet made up of 50% standard rat pellet, 20% milk powder, 6% corn starch, and 24% ghee and a cafeteria (CAF) diet such as chicken rolls, salty biscuits, cakes, and cheese snacks. Rats, Sprague-Dawley Concept Vocabulary Service. • … Sprague Dawley ® Rat Hsd:Sprague Dawley ® SD ® Custom Cardiology Models + Left Ventricular Hypertrophy - Aortic Banding Research Use Induced Hypertension + High-salt diet (13, 21, 37, 45, 51, 62) + Insulin resistance (12, 27, 50) + Sleep apnea (7) + Angiotensin (1, 6, 44, 66) + Oxidative stress (20) + Reduced nitric oxide (15, 29) + Pregnancy/Preeclampsia (2, 3, 15, 29, 55) + … A State Key Laboratory of Chemistry for Life Science and Jiangsu Key Laboratory of Molecular … The rats’ obesity was induced by a high-fat (HF) diet made up of 50% standard rat pellet, 20% milk powder, 6% corn starch, and 24% ghee and a cafeteria (CAF) diet such as chicken rolls, salty biscuits, cakes, and … The Sprague Dawley (SD) rat is often used as a general multipurpose rat model, including safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, and for surgical procedures. The effects were evaluated by organ and body weights, histopathology, and immunohistochemistry (TCRαβ, CD4, CD8, CD11b, CD68, CD103). "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. The wild-type Sprague Dawley rat thymus was comprised mostly of CD4/CD8 double positive cells whereas in the SRG rat, the viable cells recovered were CD4-/CD8- (Fig 1A–1C). Effect of shengbanfang on CYP3A1 activities of Sprague-Dawley rat] Mark. This cytosol product is prepared from sexually mature male Sprague-Dawley rat livers and characterized for sulfotransferase activity. “Hairless” rats have hair shafts shaped like a lance head (“lanceolate”). Also called Norway rat .... Sprague-Dawley rat - definition of Sprague-Dawley rat by … The study followed European Union regulations 86/609/EEC, 2010/63/EU for animal experimentation. Features/Benefits: Poole liver cytosol prepared from sexually mature male Sprague-Dawley rats high manufacturing standards to reduce lot-to-lot variability and to ensure reproducibility Available Size: 1.0 mL Protein Concentration: 20 mg/ … We investigated the possible protective effects of lycopene and curcumin on the parotid glands of 40 female Sprague Dawley rats during irradiation. These neurons consistently yield post-thaw viability in the range of 50–80%, have high neuronal purity, and are validated for functionality. The spontaneously hypertensive rat and the Lewis rat are other well-known stocks developed from Wistar rats. 2 synonyms for brown rat: Norway rat, Rattus norvegicus. shell extract in obesity induced Sprague Dawley rats. In this single-dose study, the metabonomic profile changes in the 48 h after orally administrated 3-MCPD dipalmitate at 1600 mg/kg BW to Sprague–Dawley (SD) rats were determined with liquid chromatography (LC) coupled with mass spectrometry (MS) system. subject area of . Also, Huff (2002) reported that the positive RI findings for toluene were "less than overwhelming," the negative NTP findings for vinylidene chloride "less than adequate because the use of a maximum tolerated dose [MTD] had not been clearly demonstrated," and the positive RI findings for vinylidene chloride were for "increases in leukemias and total malignant tumors in Sprague-Dawley rats … Differences in age and sex of rats should also be taken into consideration when … A number of rat species are used in research, contract research organizations and in the pharmaceutical industry including the Wistar, Sprague Dawley and Fischer 344 rat. Epub 2019 Nov 1. … IGS refers to animals bred using the Charles River International Genetic … Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. Rat Sprague Dawley Plasma from Innovative Research is manufactured using whole blood collections from Sprague Dawley rats. Microvolumes were used to analyse DNA samples. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture . injection of pentylenetetrazol (PTZ, 70–80 mg kg −1); some pups of each litter were used as controls. The chemical structures of 12 potential biomarkers for 3-MCPD dipalmitate exposures early detection were detected and … This product is manufactured in large batches, and is not available with any special instructions - if you require custom-collected material, please see our Innovative Grade US Origin Rat Sprague Dawley Plasma. The hairless mutation appeared in a SPRAGUE DAWLEY® colony in 2004; Bazzi et al. Larger impairments were found in Wistar > Fischer 344 > Dark-Agouti > Sprague-Dawley strains. Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen Yanjie Xia A, Shanmei Shen B, Xinlin Zhang A, Zhantao Deng A, Zou Xiang A, Hongwei Wang A, Long Yi A, Qian Gao A and Yong Wang A C + Author Affiliations - Author Affiliations. 2019 Dec;133(Pt B):105231. doi: 10.1016/j.envint.2019.105231. The Sprague Dawley Rat was developed by the Sprague Dawley company in 1925 from a hybrid hooded male & a female Wistar rat. We orally administered CLO at 0, 30 and 300 mg/kg/day (CLO-0, 30 and 300) to Sprague-Dawley rats for 28 days. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison, Wisconsin. The STZ-induced group received 35 mg / kg STZ by intraperitoneal injection while the STZ and HFD-induced group received the STZ after 14 days high fat diet treatment. What are synonyms for Sprague-Dawley rat? A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. Therefore the Sprague-Dawley rat liver microsomes may be useful for assessing herb-drug interaction in the hepatic first-pass metabolism responsible for CYP1A2 at the early drug-discovery stage because of similar typical substrates and metabolism activities as humans. The rats average about 5 grams of food per day per 100 grams of body weight and about 10-12 milliliters of water per 100 grams of body weight. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. In 1991, 8 colonies were selected to form the IGS Foundation Colony. From the … Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. Sprague-Dawley rat synonyms, Sprague-Dawley rat pronunciation, Sprague-Dawley rat translation, English dictionary definition of Sprague-Dawley rat. Different strains of rat differ in their sensitivity to various compounds and in their incidence of spontaneous tumors. studied the development of the hair follicle in individuals that displayed the hairless phenotype. Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat Environ Int. After a period of at least 40 days, the (adult) conditioned animals were decapitated … The subjects were adolescent male Sprague- Dawley rats aged 3 weeks divided into 3 groups. Liver S9 fractions prepared from a pool of male Sprague Dawley rats. This rat strain was first produced by the Sprague Dawley farms in Madison, Wisconsin in 1925. R. W. DAWLEY created the strain SPRAGUE DAWLEY® in 1925, and it was bred at SPRAGUE DAWLEY farm. To Charles River in 1950 from Sprague Dawley, Inc. Its main advantage is its calmness and ease of handling. Rederived into an isolator foundation colony in 1997. Sprague Dawley ® Rat Custom Reproductive Endocrinology Models + Androgen deficiency - Castration + Estrogen deficiency - Ovariectomy + Osteoporotic model - Ovariectomy and maintained on a calcium deficient diet Research Use Localized Gene Regulation + Prostate – Prostatein subunit C3, Clu (35) and Proml2 (72) + Uterus – EET1 (21), CrabpII (41), eRolDH, … Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. The aim of the current study was to compare the pharmacokinetics and hepatic metabolism in male ZDF and Sprague-Dawley (SD) rats of five antidiabetic drugs that are known to be cleared via various mechanisms. The blood glucose was measured after fasting of 12 hours, 3 days after STZ induction using the … n. The common domestic rat , which is found worldwide and is a destructive pest of crops and stored food and a carrier of disease. Antonyms for Sprague-Dawley rat. The animals were divided into 4 groups: those treated with curcumin and radiation, those treated with lycopene and … Total protein concentration: 20 mg/ml We provide liver subcellular fractions from a variety of tox species, including human, nonhuman primates (Cynomolgus Monkey and Rhesus Monkey), dog (Beagle), rat (Sprague-Dawley), mouse (CD-1 and Balb-c), and trout (Oncorhynchus mykiss). SD rats have a white coat color (albino). Synonyms for Sprague-Dawley rat in Free Thesaurus. This study aimed to validate an analytical method to determine DNA concentration using standard reference material (NIST SRM 2372) and Sprague Dawley rat and human DNA. Platform crosses, but not … The results indicated that wild rats and Long-Evans rats did not differ on any measure, with Fischer-Norway rats being only slightly inferior. CD® (Sprague Dawley) IGS Rat Details. Gibco Primary Rat Hippocampal Neurons, Sprague Dawley, are isolated and cryopreserved from Sprague Dawley embryonic day-18 rats. Sprague Dawley rat: The Sprague Dawley rat … Tao Liu (刘韬) [0] Duo Deng (邓多) [0] Zi-chao Lin (林子超) [0] Ying Pan (潘莹) [0] Wen-jing Zhou (周文菁) [0] Wang Zhou (周望) [0] Hong-bing Huang (黄红兵) [0] Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Volume 35, Issue 2, 2012, Pages 254-259. Aged 3 weeks divided into 3 groups of each litter were used as controls hairless rats. Ptz, 70–80 mg kg −1 ) ; some pups of each litter were used as controls the glands. 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